The new research project will contribute to an international effort to “delete” or illuminate each gene in the mouse genome in order to systematically examine the function of that gene on the animal’s development and health, according to a news release. This “Knockout Mouse Project” needs a comprehensive examination of the skeleton to help the research – that’s where the new grant will be implemented.
“Your skeleton changes constantly: every day your bones break down and build back up,” said Ackert-Bicknell the led of the research team and bone genetics expert. “What we’re trying to do in our study is to capture the ‘how and why’ this process becomes imbalanced, resulting in osteoporosis.”
Other major team members are David Rowe, M.D., professor of reconstructive sciences at the UConn Health Center School of Dentistry; and Dong-Guk Shin, Ph.D., professor of computer science at UConn’s bioinformatics division.
Osteoporosis affects half of all Americans older than 50 according to Ackert-Bicknell.